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  1. The most effective ones are TCAS, especially amitriptyline, and not SSRIs. No matter how much they didn't think up, they haven't come up with anything significantly better than the classics yet. Except for ketamine, but it's a niche drug that's not yet available in almost all of the world, except in the United States.

    Remember that 1/3 of depressions are resistant, i.e. they do not respond to any treatment.

    How is the effectiveness of a drug determined? Hundreds of scientists and medical professionals around the world test them on cohorts of patients and compare them, often just with placebo, then someone takes and combines their results into one meta-analysis and makes a general conclusion. As a result, there are thousands and thousands of patients in the sample. Your particular case is statistically irrelevant. Both the most ineffective and the most effective drug can help you. If you're lucky.�

    See, 1/3 – resistant depressions, another 1/3 is a weak effect or not the effect that was expected. As a result, only about 30% of patients with depression are clearly cured with the help of drugs. Now think about how likely it is that you will end up in 70% of patients where there is no effect or it is weak, especially if you are not taking the most effective drug of its kind? The effect of treatment is not a given, not “yes, it helped” or”no, it didn't help”. This is a matter of probabilities. And there are many of them and it is difficult to calculate them.

    The question of the effectiveness of the drug does not exclude the problem of side effects, because of which you may have, at least, discomfort.

    Do not forget that the current guidelines for the treatment of mental disorders strongly advise combining pills with psychotherapy for greater effectiveness. True, the guys never make a note that this is fucking expensive in terms of money.

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