3 Answers

  1. An overabundance of serotonin will lead to serotonin syndrome, which in turn will lead to death or, in a milder version, to serotonin failure, and this is depression. This is associated with such a phenomenon as Tuesday blues, mdma taken on Saturday night depletes serotonin reserves, the very minimum of which falls on Tuesday, which jumps the number of suicides.

    Dopamine is more interesting, because in addition to the reward system for action/learning, it is responsible for sexual arousal. When there is an overabundance of dopamine, the number of receptors decreases, which in the long run means a decrease in libido and learning ability. In advanced cases, agedonia may develop – a decrease or loss of the ability to enjoy any actions.

    An overabundance of dopamine is also found in schizophrenics and people with Parkinson's disease.

  2. If I'm not mistaken, Anatoly Wasserman wrote in the article “narcotic immunity” that the immune system reacts to, say, a large amount of serotonin by starting to destroy / inhibit the organ that produces serotonin. So much for the consequences of increasing serotonin / dopamine – you simply won't have “your” harmons, but only “borrowed”ones. The immune system “thinks” that the organ that produces serotonin/dopamine is too big/painfully powerful and almost “shoots” it, and the important thing is that the opposite is impossible – the cut / killed piece will not recover. This is the problem with long-term mephedrone users: mephedrone burns out the receptors, and the immune system produces harmons of joy. Immunity is activated due to the fact that there is 9 times more serotonin and 5 times more dopamine(I'm not sure about the numbers, but many times more than normal). Something like that…

  3. There are many variables, many different scenarios, many ways. People are also noticeably different.
    I'll try to make it shorter.
    The organism is a dynamic system and strives for homeostasis. By increasing the concentration of the mediator changes in gene expression will occur and the sensitivity of the receptors will decrease=>the system will approach the equilibrium (initial) state, usually greatly reducing the effectiveness of our venture (up to 0)

    Is it possible? Yes, in some cases it is possible.
    Do I need to? Usually not necessary
    Will it make anyone feel better? Healthy people will usually get worse-after all, the side effects. For Parkinson's patients, increasing the dopamine concentration may help. Patients with depression (medical diagnosis) can help. In certain scenarios, it can be very harmful (provoke psychosis, change, or more precisely, phase inversion in bipolar disorder, etc.).

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