2 Answers

  1. Good afternoon, depression most often has a psychological inorganic nature, but just in case, a psychiatrist can prescribe laboratory tests to exclude an organic cause! In addition to checking thyroid function (tests for TSH, t4 sv., t3 sv., anti-TPO), it is advisable to check the level of other hormones (FSH, LH, prolactin, cortisol), as well as additional laboratory diagnostics:

    • the sum level. Vitamin D (25-OH)

    • ferritin

    • general blood test with leukocyte formula

    • biochemical analysis, basic.

  2. The good news is that a diagnosis of major depressive disorder can be made with very high accuracy based on a blood and/or urine test. Finally, we are waiting for clinically relevant tests. The idea is that a number of markers are checked and the scores are summed up – if you exceed the threshold level for a number of indicators , you have depression. There is no single indicator of depression.

    Blood (Papakostas et al., 2013): Alpha 1 antitrypsin, Apolipoprotein CIII, Myeloperoxidase, Soluble TNF a receptor II, Cortisol, Epidermal growth factor, Prolactin, Resistin, Brain-derived neurotrophic factor.

    Моча (Zheng et al., 2013): sorbitol, uric acid, azelaic acid, quinolinic acid, hippuric acid, and tyrosine.

    The bad news is that the technique is new, it is absent in the post-Soviet space as a phenomenon, and it is not known when it will appear at all. Alternatively, you can pay out half a bucket of gold to a familiar laboratory assistant – he will get you reagents and conduct tests for you personally, but this is very difficult and impractical. Go better to a therapist and take a special course. psychological tests. Their effectiveness is quite decent, it is an inexpensive and simple procedure. According to the recommendations for doctors, it is psychological tests that are the basis for making a diagnosis of “depression”, and not laboratory tests. Therefore, their results are not an argument for the doctor – it's a waste of money. And the thyroid gland should be monitored without any depression.

    I, of course, am not a doctor, but a biologist and I will say that the analysis of whether it is thyroid hormones, whether it is the metabolites of dopamine and serotonin – these are indirect indicators that do not have 100% specificity for depression. Although it is clear that if there are violations in these indicators, “mood disorders”, as they are called abroad, are very likely.

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